Publications

2026

Spotlight on innovation: key insights from the extracellular vesicle cluster meeting at the European Innovation Council Adamo G, Amarantos I, Arzimanoglou I, Bergese P, Bongiovanni A, Bussolati B, Cauda V, Chiari M, Garinis, G A, Giebel B, Guazzi P, Jurga M, Neri C, Ohlsson P, Rohde E, Sales G, Trapani I, Vader P, Vainio S, Wauben M H M, Yáñez-Mó M, Zarovni N. Cytotherapy. 2026 Jan. Doi: 10.1016/j.jcyt.2025.08.008

Exploring the role of extracellular vesicles in otorhinolaryngology: From diagnostics to therapeutic potential Fotouhi F, Nokhbedehghan Z, Khajavi M, Taghizadeh-Hesary F, Alizadeh R, Asghari A, Daneshmehr M, Warnecke A, Rohde E, Gimona M, Davachi SM, Aleemardani M, Bagher. International Journal of Pharmacy and Pharmaceutical Science. 2026 Jan. Doi: 10.1016/j.ijpharm.2026.126634

From Lab to Industry: Advancing the Translational Potential of Extracellular Vesicles Through the ISEV Translation, Regulation and Advocacy Committee (ISEV-TRA) Gurriaran-Rodriguez U, Bussolati B, Gimona M, Glebov K, Fujita Y, Marcilla A, Neri C, Fu QL, Das S, Pluchino S, Zarovni N, Salomon C, Witwer K, Falcon-Perez JM. Journal of Extracellular Vesicles. 2026 Jan Doi: 10.1002/jev2.70220 PMID: 41531372

2025

Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics Gil Izquierdo S, Fernández Pilar A, Rios J L, Lim K S, Toh W S, Liu C, Gimona M, Gawlitta D, Man K. Journal of Nanobiotechnology. 2025 Dec. Doi: 10.1186/s12951-025-03906-w

An Anti-Myd88 Peptide Synergistically Enhances the Anti-Inflammatory Effects of Extracellular Vesicles from Naïve Umbilical Cord MSC or HEK293F CD24 Overexpressing Cells Abas B I, Bergqvist M, Yu L, Wang Y, Gimona M, Park K-S & Lötvall. Journal of Advanced Materials Interfaces. 2025 Aug. Doi: 10.1002/admi.202500252

Quantitative characterisation of extracellular vesicles designed to decoy or compete with SARS-CoV-2 reveals differential mode of action across variants of concern and highlights the diversity of Omicron Schürz M, Pagani I, Klinglmayr E, Melo Benirschke H, Mayora Neto M, Galietta LJV, Venturini A, Pedemonte N, Capurro V, Laner-Plamberger S, Grabmer C, Emminger E, Wolf M, Steiner M, Kohlmetz C, Mayr N, Paniushkina L, Schallmoser K, Strunk D, Brandstetter H, Hintersteiner M, Temperton N, Vicenzi E, Meisner-Kober N. Journal of Cell Communication and Signaling. 2025 Jul. Doi: 10.1186/s12964-025-02223-x

First-In-Human Application of Human Umbilical Cord-Derived Extracellular Vesicles in Tethered Spinal Cord Release Surgery Krause M, Gburek-Augustat J, Gräfe D, Metzger R, Ginzel M, Griessenauer CJ, Grassner L, Weghuber D, Gradl J, Auer D, Schally T, Rund S, Kals C, Folie C, Bayer E, Gimona M, Rohde E. Journal of Extracellular Vesicles. 2025 Jun. Doi: 10.1002/jev2.70104

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation Luteijn MJ, Bhaskar V, Trojer D, Schürz M, Mahboubi H, Handl C, Pizzato N, Pfeifer M, Dafinca R, Voshol H, Giorgetti E, Manneville C, Garnier IPM, Müller M, Zeng F, Buntin K, Markwalder R, Schröder H, Weiler J, Khar D, Schuhmann T, Groot-Kormelink PJ, Keller CG, Farmer P, MacKay A, Beibel M, Roma G, D’Ario G, Merkl C, Schebesta M, Hild M, Elwood F, Vahsen BF, Ripin N, Clery A, Allain F, Labow M, Gabriel D, Chao JA, Talbot K, Nash M, Hunziker J, Meisner-Kober N. Nucleic Acids Research. 2025 Apr. Doi: 10.1093/nar/gkaf253

On the road: extracellular vesicles in intercellular communication Wessler S. & Meisner-Kober N.  Journal of Cell Communication and Signaling. 2025 Feb. Doi: 10.1186/s12964-024-01999-8

Long-Term Retrospective Analysis of Parvovirus B19 Infections in Blood Donors (2012-2024): Significant Increase in Prevalence Following the SARS-CoV-2 Pandemic Oeller M, Kartal O, Trifonova I, Held N, Hoeggerl AD, Neureiter H, Lauth W, Grabmer C, Rohde E, Laner-Plamberger S. Diagnostics (Basel). 2025 Sep. Doi: 10.3390/diagnostics15182313

Stable SARS-CoV-2 antibody levels and functionality in serum and COVID-19 convalescent plasma after long-term storage Laner-Plamberger S, Siller A, Lauth W, Kern JM, Baskova L, Held N, Kartal O, Schennach H, Rohde E, Grabmer C. Vox Sanguinis. 2025 Aug. Doi: 10.1111/vox.70059

Distinct miRNA profiles in human amniotic tissue and its vesicular and non-vesicular secretome Chaves-Solano N, Kau-Strebinger S, Oesterreicher J, Pultar M, Holnthoner W, Grillari J, Hennerbichler S, Brandstetter A, Spittler A, Hackl M, Wolbank S, Banerjee A, Weidinger A. Frontiers in Cell and Developmental Biology. 2025 Oct. Doi: 10.3389/fcell.2025.1692501

Anatomical implant region – a critical determinant for the osteogenic potency of small extracellular vesicles and rhBMP-2 Deininger C, Wagner A, Wichlas F, Rohde E, Freude T, Deluca A, Fierlbeck J, Holzleitner M, Senck S, Tempfer H, Gimona M, Traweger A. European Journal of Trauma and Emergency Surgery. 2025 Dec. Doi: 10.1007/s00068-025-03036-w

International Society of Cell and Gene Therapy 2025 exosomes signature series: a thematic synthesis for advancing mesenchymal stromal cell-derived extracellular vesicle therapies Tertel T, Giebel B, Lee R H, Muraca M, Ortiz L A, Parolini O, Perruche S, Robbins P D, Rohde E, Strader S R, Terai S, Toh Wei S, Yarani R, Weiss D J, Wiest E F, Lim Sai K. Cytotherapy. 2025. Doi: 10.1016/j.jcyt.2025.102016

2024

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats Deluca A, Wagner A, Heimel P, Deininger C, Wichlas F, Redl H, Rohde E, Tempfer H, Gimona M, Traweger A. Stem Cell Research & Therapy. 2024 May. Doi:10.1186/s13287-024-03755-8

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches Welsh J A, Goberdhan D C I, O’Driscoll L, Buzas E I, Blenkiron C, Bussolati B, Cai H, Di Vizio D, Driedonks T A P, Erdbrügger U, Falcon-Perez J M, Fu Q L, Hill A F, Lenassi M, Lim S K, Mahoney M Ỹ G, Mohanty S, Möller A, Nieuwland R, Ochiya T, Sahoo S, Torrecilhas A C, Zheng L, Zijlstra A, Abuelreich S, Bagabas R, Bergese P, Bridges E M, Brucale M, Burger D, Carney R P, Cocucci E, Crescitelli R, Hanser E, Harris A L, Haughey N J, Hendrix A, Ivanov A R, Jovanovic-Talisman T, Kruh-Garcia N A, Faustino, V K L, Kyburz D, Lässer C, Lennon K M, Lötvall J, Maddox A L, Martens-Uzunova E S, Meisner-Kober N, Nawaz M, Wolf, M. Journal of Extracellular Vesicles. 2024 Feb. Doi: 10.1002/jev2.12404

Selected publications until 2023

High efficiency preparation of monodisperse plasma membrane derived extracellular vesicles for therapeutic applications Alter C L, Detampel P, Schefer R B, Lotter C, Hauswirth P, Puligilla R D, Weibel V J, Schenk S H, Heusermann W, Schürz M, Meisner-Kober N, Palivan C, Einfalt T, Huwyler J. Communications Biology. 2023 Dec. Doi: 10.1038/s42003-023-04859-2

Cell culture-derived extracellular vesicles: Considerations for reporting cell culturing parameters Shekari F, Alibhai FJ, Baharvand H, Börger V, Bruno S, Davies O, Giebel B, Gimona M, Salekdeh GH, Martin-Jaular L, Mathivanan S, Nelissen I, Nolte-‘t Hoen E, O’Driscoll L, Perut F, Pluchino S, Pocsfalvi G, Salomon C, Soekmadji C, Staubach S, Torrecilhas A C, Shelke G V, Tertel T, Zhu D, Théry C, Witwer K, Nieuwland R.J. Journal of Extracellular Biology. 2023 Oct. Doi: 10.1002/jex2.115

Quantitative and functional characterisation of extracellular vesicles after passive loading with hydrophobic or cholesterol-tagged small molecules Tréton G, Sayer C, Schürz M, Jaritsch M, Müller A, Matea C-T, Stanojlovic V, Da Costa Melo Benirschke H, Be C, Krembel C, Rodde S, Haffke M, Hintermann S, Marzinzik A, Ripoche S, Blöchl C, Hollerweger J, Auer D, Cabrele C, Huber C G, Hintersteiner M, Wagner T, Lingl A, Meisner-Kober N. Journal of Controlled Release. 2023 Sep. Doi: 10.1016/j.jconrel.2023.08.010

A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles” Toh WS, Yarani R, El Andaloussi S, Cho BS, Choi C, Corteling R, De Fougerolles A, Gimona M, Herz J, Khoury M, Robbins PD, Williams D, Weiss DJ, Rohde E, Giebel B, Lim SK. J. Cytotherapy. 2023 Aug. Doi: 10.1016/j.jcyt.2023.02.009

Surface display of functional moieties on extracellular vesicles using lipid anchors Zheng W, Schürz M, Wiklander R J, Gustafsson O, Gupta D, Slovak R, Traista A, Coluzzi A, Roudi S, Barone A, Farcas D, Kyriakopoulou E, Galli V, Sharma H, Meisner-Kober N, Hocharenko M, Andaloussi S E L. Journal of Controlled Release. 2023 May. Doi: 10.1016/j.jconrel.2023.04.033

Evaluation of the Potential of Umbilical Cord Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles to Improve Rotator Cuff Healing: A Pilot Ovine Study Jenner F, Wagner A, Gerner I, Ludewig E, Trujanovic R, Rohde E, von Rechenberg B, Gimona M, Traweger A. The American Journal of Sports Medicine. 2023 Feb. Doi: 10.1177/03635465221145958

EVAnalyzer: High content imaging for rigorous characterisation of single extracellular vesicles using standard laboratory equipment and a new open-source ImageJ/Fiji plugin Schürz M, Danmayr J, Jaritsch M, Klinglmayr E, Da Costa Melo Benirschke H, Matea C-T, Zimmerebner P, Rauter J, Wolf M, Gueths-Gomes F, Kratochvil Z, Heger Z, Miller A, Heuser T, Stanojlovic V, Kiefer J, Plank T, Johnson L, Himly M, Blöchl C, Huber C G, Hintersteiner M, Meisner-Kober N. Journal of Extracellular Vesicles. 2022 Nov. Doi: 10.1002/jev2.12282

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review Lima T S M, Souza W, Geaquinto L R O, Sanches P L, Stepień E L, Meneses J, Gortari E F-D, Meisner-Kober N, Himly M, Granjeiro J M, Ribeiro A R. Journal of Nanomaterials. 2022 Apr. Doi: 10.3390/nano12071231

Synergy of Human Platelet-Derived Extracellular Vesicles with Secretome Proteins Promotes Regenerative Functions Gomes F G, Andrade A C, Wolf M, Hochmann S, Krisch L, Maeding N, Regl C, Poupardin R, Ebner-Peking P, Huber C G, Meisner-Kober N, Schallmoser K, Strunk D. Biomedicines. 2022 Jan. Doi: 10.3390/biomedicines10020238

Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule – single vesicle level by fluorescence correlation spectroscopy and single particle imaging Corso G, Heusermann W, Trojer D, Görgens A, Steib E, Voshol J, Graff A, Genoud C, Lee Y, Hean J, Nordin JZ, Wiklander OPB, El Andaloussi S, Meisner-Kober N. Journal of Extracellular Vesicles. 2019 Sep Doi: 10.1080/20013078.2019.1663043

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER Heusermann W, Hean J, Trojer D, Steib E, von Bueren S, Graff-Meyer A, Genoud C, Martin K, Pizzato N, Voshol J, Morrissey DV, Andaloussi SE, Wood MJ, Meisner-Kober N. Journal of Cell Biology. 2016 Apr. Doi: 10.1083/jcb.201506084

The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing Stalder L, Heusermann W, Sokol L, Trojer D, Wirz J, Hean J, Fritzsche A, Aeschimann F, Pfanzagl V, Basselet P, Weiler J, Hintersteiner M, Morrissey DV, Meisner-Kober N. EMBO Journal. 2013 Apr  Doi: 10.1038/emboj.2013.52